Caffeine Pretreatment Increases Survival of DBAXC57BL Mice Exposed to Different Doses of γ– Radiation by Glutathione Elevation

 Abstract

Humans are exposed to ionizing radiations from various sources including background, air or space travel and diagnostic and cancer therapy. The deleterious changes induced by ionizing radiations can be reduced using different pharmacophores. The effect of 80 mg/kg body weight of caffeine was studied on the radiation-induced sickness and mortality in DBAxC57BL mice exposed to 7 to 13 Gy of -irradiation. Treatment of mice with caffeine one hour before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared to saline treated irradiated controls. Caffeine provided protection against both the gastrointestinal and hemopoietic deaths. However, animals of both the Caffeine and Saline pretreated irradiation groups did not survive up to 30 days post-irradiation beyond 11 Gy irradiation. The LD50/30 was found to be 9.4 Gy for the Saline and 10.2 Gy for caffeine pretreated irradiation group, respectively with a dose reduction factor of 1.1. The ability of caffeine to protect mice against the radiation induced mortality is due to increase in glutathione accompanied by a reduced lipid peroxidation on 31days in the survivors. Caffeine protected the DBAxC57BL mice against radiation induced sickness and mortality by increasing glutathione and depleting lipid peroxidation.

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